Vanquish UHPLC System


Since its inception, high-performance liquid chromatography has increased it’s technological enhancements in all aspects, whether that’s improvements in detectors, better accuracy, and precision or new column chemistries. Now, most of the advances have been centered on performing faster separations through the advent of UHPLC (ultra-high-performance liquid chromatography) complemented by smaller column particles and diameters. All of these developments have given rise to increases in productivity, but what actually is productivity?

Productivity for liquid chromatography, it has many beneficial outcomes, such as higher throughput, reduced cost per sample, greater return-on-investment for high-value instrument purchases, and basically a faster route from sample to knowledge.

The future for HPLC is focused on productivity. Technology enhancements that are offering more pump pressure, reducing column particle sizes and diameters, or simply offering better system performance and robustness, all increase productivity. They will increase throughput and drive down cost per sample.

Thermo Scientific Vanquish UHPLC systems are the most advanced UHPLC instruments available. The new Vanquish platform was designed from the ground up to improve performance and repeatability with no trade-offs in quality, robustness, or ease-of-use. Vanquish platform users have all they need to solve their toughest analytical challenges with confidence.

For any application—whether HPLC or UHPLC, small or large molecules, simple or complex mixtures—the Vanquish platform was designed to handle it all. This innovative, simple-to-operate, and easy-to-maintain platform delivers confident separations that push chromatographic boundaries. Regardless of the configuration you choose, you will get a highly integrated solution with optimal fluidic connections, providing unsurpassed retention time and peak area precision.

You will also benefit from the industry-leading, easy-to-use, and compliant Thermo Scientific Chromeleon Chromatography Data System (CDS) with eWorkflow method setup, dedicated ePanels, Open Access, and smart tools. Chromeleon CDS delivers advanced system communication with single-point intelligent control and functionality. It also provides direct plugins for the Vanquish system to other manufacturers’ chromatography data systems.

Vanquish UHPLC system offer three kinds of platform.

  1. Vanquish Horizon UHPLC System

For your most complex and difficult samples, or for applications where you are aiming for the shortest cycle times and highest throughput. Vanquish Horizon UHPLC system allows for smaller particles and column dimensions to be run with greater confidence for the most demanding LC and LC-MS workflows.

  1. Vanquish Flex UHPLC Systems

For assays that require more flexibility in solvents to accommodate all applications. Vanquish Flex UHPLC systems excel from method development to routine analyses. With binary and quaternary pump options, the Vanquish Flex UHPLC systems offer outstanding performance for targeted LC and LC-MS workflows.

  1. Vanquish Duo UHPLC Systems

Increase productivity, up-time, and sample knowledge for a faster return on investment. Vanquish Duo UHPLC systems expands the benefits of the Vanquish platform through two flow paths to support three workflows (dual, tandem and inverse gradient) within one integrated UHPLC system. With the addition of the second flow path, improve your productivity by saving time, cost per sample without added bench space, and without compromising performance, robustness or ease-of-use.

Comparison of Vanquish UHPLC systems

Vanquish Horizon UHPLC Systems

Vanquish Flex UHPLC Systems

Vanquish Duo UHPLC systems

Unrivaled performance and throughput for applications requiring high-end UHPLCBinary or quaternary solvent blending for fast and reliable UHPLC or flexible method developmentIncrease productivity with two flow paths to support three workflows
System pressureUp to 1500 barUp to 1000 barUp to 1500 bar
Retention time precisionBestBetterBest
Flow range5 mL/min8 mL/min8 mL/min
System componentsPumpVanquish Binary Pump HVanquish Binary Pump FVanquish Dual Pump F
The pump with the highest backpressure at 1500 bar, and ideal for any gradient performance from shallow to ballisticUHPLC performance for demanding routine applications up to 1000 barUniquely provides two independent ternary-solvent blending flow streams in one device up to 1000 bar
The instrument can also be configured with a combination of Vanquish Horizon or Vanquish Flex pumps
Vanquish Quaternary Pump F
UHPLC performance with more solvent flexibility up to 1000 bar
AutosamplerVanquish Split Sampler HTVanquish Split Sampler FTVanquish Dual Split Sampler FT/HT
Excellent precision, accuracy, and short cycle times with innovative air-stream cooling and barcode reading for inventory management for all workflows up to 1500 barEnjoy the same benefits as the Vanquish Split Sampler HT for applications up to 1000 barA unique sampler that combines two injection devices in one housing resulting in two separate channels that are individually controllable (Inj. volume, wash cycles, etc.) with a 1000 bar or 1500 bar option
The instrument can also be configured with a single Vanquish Split Sampler HT/FT
Extended sample capacityVanquish Charger
An intelligent, robotic rack and plate feeder that automatically loads samples in the autosampler and extends the sample capacity of all Vanquish samplers to up to 8832 samples (23 well plates or 12 vial racks) with innovative air-stream cooling and barcode reading for inventory management
Column compartmentVanquish Column Compartment
Provides two-column thermostatted modes (still and forced air), active and passive solvent pre-heating and post-column cooling for optimized control of your separations and advanced method transfer


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