For researchers pursuing the next scientific breakthrough, the Thermo Scientific Vanquish Neo UHPLC system delivers maximum performance 24/7 for reproducible nano-, capillary-, and micro-flow LC-MS. Combining a high degree of innovation with the best-in-class Vanquish platform enhances productivity for novice and expert LC-MS users alike.


All-in-one nano-, capillary-, and micro-flow LC

Thermo Scientific ProFlow™ XR active flow control pump technology delivers excellent retention time precision from nano up to 100 μL/min at pressures up to 1500 bar. Vial bottom detection enables injections from volume-limited samples.

Accelerated productivity

Fast sample loading, column equilibration, and ultra-low system gradient delay volume reduce method overhead time, improving sample throughput while enhancing MS utilization.

Maximized performance

Unique low-flow split-loop autosampler design limits sample dispersion reduces system carryover and maximizes sample usage. The metering device improves quantitation through high injection volume linearity, precision, and accuracy.

Long-term, trouble-free analysis

Next-generation Thermo Scientific SmartInject technology improves column lifetime and retention time precision. Maintenance-free 1500 bar compatible ceramic valves and near-zero dead volume Thermo Scientific Viper and nanoViper fittings minimize leaks with the robust long-term operation.

Intelligent operation

The Thermo Scientific Vanquish User Interface provides walk-up and remote system monitoring and control with automated procedures and guided instrument maintenance and troubleshooting scripts, improving productivity for all users. The intelligent method editor wizard ensures the compatibility of method parameters with installed consumables.

Seamless LC-MS integration

The Vanquish Neo UHPLC system excels at high-sensitivity LC-MS applications and seamlessly integrates with the Thermo Scientific mass spectrometry portfolio through a comprehensive suite of ESI sources. Harness speed, robustness, and sensitivity with triple quadrupole MS systems or resolution, mass accuracy, and versatility with Thermo Scientific Orbitrap MS systems.


Detector options

Choosing the right detector(s) ensures that you can detect your target compound with confidence. Thermo Scientific HPLC and UHPLC systems can be combined with a variety of HPLC detectors that can be mixed and matched for complimentary analysis, and are all seamlessly controlled with the rest of the system using Thermo Scientific Chromeleon Chromatography Data System (CDS) for easy data acquisition and processing.

Available detector types include:

  • UV/Vis absorption detection
  • Fluorescence detection
  • Charged aerosol detection
  • Mass spectrometry for LC-MS applications

Method transfer tools

Transferring methods between systems and labs are made easier with Thermo Scientific HPLC and UHPLC systems. Built-in features of select systems facilitate method transfer by including an adjustable system gradient delay volume, multiple column thermostatting modes , and automated sample in-needle dilution, all of which are easily adjusted using the Chromeleon CDS software interface. Our method transfer tools allow you to duplicate other HPLC vendors’ system settings to more easily replicate methods, such as those from a Waters™ Alliance™ HPLC systemAgilent™ 1260 Infinity™ LC system, and Shimadzu™ Nexera-i™ system to a Vanquish Core HPLC system.

Precise gradient delivery

Thermo Scientific SmartFlow technology in Thermo Scientific Vanquish and UltiMate 3000 HPLC and UHPLC pumps automatically compensates for changing eluent compressibility to deliver the precise performance and flexibility for reproducible separations. This technology ensures highly accurate and precise flows, independent of eluent composition and backpressure.

Additionally, SmartStroke technology in the Thermo Scientific Vanquish Horizon binary pump can virtually eliminate the TFA baseline ripples even with small mixer volumes for lower gradient delay volume (GDV) and higher sensitivity.

Optimized HPLC consumables

To help you achieve better results and maximize your investment, we offer a full range of innovative, reliable chromatography consumables to meet your analytical challenges. These products are tested using the latest Thermo Scientific chromatography instruments, so you can be assured that our consumables are the perfect fit for your chromatography systems.

We offer:

  • HPLC and UHPLC columns
  • Autosampler vials and well plates
  • Sample preparation
  • HPLC standards, reagents & solvents

and many more features, please visit: Thermo Fisher Scientific – Vanquish Neo UHPLC

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