The Thermo Scientific Orbitrap Eclipse Tribrid mass spectrometer surpasses these limits with new innovations that deliver the ultimate flexibility to expand the experimental scope, and with built-in intelligence to ensure the highest data quality and confidence. One system provides maximum insights, so you productively go beyond today’s discovery.

This newest Tribrid platform includes Advanced Ion Management Technology (AIM+) with the new QR5 segmented quadrupole mass filter, Real-Time Search, Enhanced Vacuum Technology, optional Proton Transfer Charge Reduction (PTCR), and optional High Mass Range MSn (HMRn) mode. Collectively, these features make this instrument uniquely suited for accurate and high-throughput full-proteome quantitation, characterization of complex mixtures of protein or small molecule-based pharmaceuticals, and deciphering higher-order protein structures. The Thermo Scientific™ Orbitrap Eclipse Tribrid MS makes it easy to tackle these difficult analyses and collect the high-quality data required to drive the right decisions, pushing your science beyond today’s discovery.

Key capabilities are Active Ion Management (AIM+) Technology that includes the QR5 segmented quadrupole mass filter with hyperbolic surfaces, maximizes ion transmission to achieve unprecedented levels of qualitative and quantitative performance. Real-Time Search enables faster data acquisitions and improved specificity, significantly increasing the analytical performance of TMT-based quantification experiments. Thermo Scientific™ TurboTMT mode improves HRAM MSn acquisition rates in TMT experiments. Thermo Scientific™ Precursor Fit filter enables precursor ion selection for a defined specificity. Enhanced Vacuum Technology improves Thermo Scientific™ Orbitrap™ mass analyzer performance. Improved accumulation and transmission of high molecular weight ions to the ion trap and Orbitrap mass analyzers. Optional Proton Transfer Charge Reduction (PTCR) simplifies MSn spectra of multiply charged analytes. Optional High Mass Range MSn (HMRn) mode provides expanded mass range capabilities for comprehensive MSn characterization of intact proteins and protein complexes

This Unique Tribrid architecture includes a quadrupole mass filter, and dual-pressure linear ion trap and Orbitrap mass analyzers, allowing for high acquisition rates to provide maximum experimental flexibility for dissociation and detection of fragment ions also improved high-sensitivity atmospheric pressure interface combines a high capacity transfer tube and electrodynamic ion funnel, providing an increased ion flux and lower limits of detection for a wide range of molecules. Advanced active ion beam guide (AABG) prevents neutrals and high-velocity clusters from entering the resolving quadrupole. Ultra-high-field Orbitrap mass analyzer provides ultra-high resolution and highest acquisition rates. Acquisition rates of up to 40 and 45 Hz for Orbitrap mass analyzer and linear ion trap MSn experiments, respectively. Orbitrap resolution up to 500,000 FWHM at m/z 200; optional resolution up to 1,000,000 FWHM. Large surface area ion trap detector for significantly improved robustness and lifetime. Full parallelization of MS and MSn analyses with Dynamic Maximum Injection Time and Synchronous Precursor Selection (SPS) for MSn experiments

There is an Optional Compact Electron Transfer Dissociation  (ETD)/PTCR ion source based on Townsend discharge with extremely stable anion flux for improved usability and reagent longevity. Multiple fragmentation techniques: collision-induced dissociation (CID), higher-energy collisional dissociation (HCD), optional ETD (including electron-transfer higher-energy collision dissociation, or EThcD, and electron transfer collision-induced dissociation, or ETciD) and optional ultraviolet photodissociation (UVPD), available at any stage of MSn with detection in the Orbitrap mass analyzer or linear ion trap analyzer. Advanced Peak Determination (APD) for improved precursor annotation in data-dependent experiments. Universal Method maximizes peptide identifications without method optimization when sample concentration is unknown. Intuitive, flexible drag-and-drop instrument method editor simplifies method development and the creation of unique analytical workflows. Extensive method template library. Thermo Scientific™ AcquireX data acquisition provides all-inclusive, automated small molecule sample profiling on an LC timescale. Streamlined calibration routines with improved Orbitrap calibration for ions with m/z <200.

Today’s cutting-edge research pushes LC-MS to its limits. Obtaining high confidence insights to enable accurate resolution of subtle differences and avoid costly dead-ends is needed faster than ever before.

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